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. Author manuscript; available in PMC: 2016 May 4.
Published in final edited form as: Expert Opin Pharmacother. 2014 Sep 29;15(16):2443–2459. doi: 10.1517/14656566.2014.965142

Figure 1. Mechanisms of proteasome inhibitor lethality.

Figure 1

Modified with permission from [39].

Bad: Bcl-2-associated death promoter; Bim: Bcl-2 interacting mediator of cell death; DNMT1: DNA methyltransferase 1; ER: Endoplasmic reticulum; FLIP: FLICE-like inhibitory protein; IAP: Inhibitor of apoptosis; JNK: c-Jun N-terminal kinase; ROS: Reactive oxygen species; TRAIL: TNF-related apoptosis-inducing ligand; UPR: Unfolded protein response.