Table 6.
Comparison of different four-arm trial designs of size T = 423. Fa: Fisher's adjusted test; α: family-wise type-I error; 1 − β: power; p*: expected proportion of patients in the trial assigned to the best treatment; ENS: expected number of patient successes; UB: upper bound
| Crit. value |
H0 : p0 = pi = 0.3 for i = 1, …, 3 |
H1 : p0 = pi = 0.3, i = 1, 2, p3 = 0.5 |
|||||
|---|---|---|---|---|---|---|---|
| α | p* (s.e.) | ENS (s.e.) | (1 − β) | p* (s.e.) | ENS (s.e.) | ||
| FR | 2.128 | 0.047 | 0.250 (0.02) | 126.86 (9.41) | 0.814 | 0.250 (0.02) | 148.03 (9.77) |
| TS | 2.128 | 0.056 | 0.251 (0.07) | 126.93 (9.47) | 0.884 | 0.529 (0.09) | 172.15 (13.0) |
| UCB | 2.128 | 0.055 | 0.251 (0.06) | 126.97 (9.41) | 0.877 | 0.526 (0.07) | 171.70 (11.9) |
| RBI | 2.128 | 0.049 | 0.250 (0.03) | 126.77 (9.40) | 0.846 | 0.368 (0.04) | 158.34 (10.4) |
| RGI | 2.128 | 0.046 | 0.250 (0.03) | 126.80 (9.36) | 0.847 | 0.358 (0.03) | 157.26 (10.3) |
| CB | Fa | 0.047 | 0.269 (0.39) | 126.89 (9.61) | 0.213 | 0.677 (0.41) | 184.87 (36.8) |
| GI | Fa | 0.048 | 0.248 (0.18) | 126.68 (9.40) | 0.428 | 0.831 (0.10) | 198.25 (13.7) |
| CG | 2.128 | 0.034 | 0.250 (0.02) | 127.16 (9.46) | 0.925 | 0.640 (0.08) | 182.10 (12.3) |
| UB | 126.90 (0.00) | 1 | 211.50 (0.00) | ||||