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. 2016 May 4;12(5):e1005617. doi: 10.1371/journal.ppat.1005617

Fig 5. Mnn10 is not required for C. albicans systemic infection in athymic nude mice.

Fig 5

BALB/c mice or athymic nude mice (BALB/c background) were infected with 3×105 CFU of SN152, mnn10Δ/Δ::MNN10 or mnn10Δ/Δ strain via lateral tail vein, respectively. The kidney and liver fungal burdens of BALB/c mice (n = 8 per group) (A) and athymic nude mice (n = 6 per group) (B) 5 days after infection. *, P < 0.05; **, P < 0.01 (Kruskal-Wallis nonparametric One-way ANOVA with Dunns post-test). (C) The kidney fungal burdens of athymic nude mice (n = 6 per group) 10 days after infection. (D) Survival of athymic nude mice infected with the indicated C. albicans (n = 8 per group). (E) Survival of SN152 and mnn10Δ/Δ infected athymic nude mice treated with combination of IFN-γ (100 ng) and IL-17 (100 ng) or the same volume of sterile saline. Data shown are representative of three independent experiments. **, P < 0.01 (mnn10Δ/Δ+IFN-γ and IL-17 versus mnn10Δ/Δ+saline); *, P < 0.05 (mnn10Δ/Δ+IFN-γ and IL-17 versus SN152+IFN-γ and IL-17) [Kruskal-Wallis nonparametric One-way ANOVA with Dunns post-test (A, B, C) and Log-rank test (D, E)].