Table 2. Serum cytokine & alarmin concentrations (mean value ± SEM); NT-T (normothermic trauma), NT-S (normothermic sham), HT-T (hypothermic trauma), HT-S (hypothermic sham), statistical significance p = <0.05 (^a) from sham, ^b) from baseline, ^c) NT-T vs. HT-T).

		0h	2.5h	14h	24h	48h
IL-6 (pg/ml)	NT-T	32.29 ±24.99	41.10 ±25.60	62. 35 ±38.12 a) b)	71.95 ±54.76 a) b)	79.69 ±58.59 a) b)
	NT-S	29.80 ±35.22	24.04 ±17.64	22.48 ±14.26	24.07 ±14.63	30.87 ±23.28
	HT-T-S	42.28 ±14.66	41.54 ±24.73	82.01 ±47.48 a) b)	86.23 ±35.93 a) b)	114.30 ±70.74 b)
	HT-S	40.44 ±2.67	52.29 ±5.41b)	41.71 ±20.31	43.22 ±16.75	66.29 ±35.37
IL-8 (pg/ml)	NT-T	156.29 ±32.96	140.62 ±41.24	148.90 ±25.85	161.78 ±32.92 a)	139.71 ±34.44
	NT-S	161.72 ±13.50	161.58 ±9.96	178.99 ±5.01	108.90 ±36.92	166.29 ±43.33
	HT-T	168.53 ±38.97	163.46 ±19.16 a)	157.41 ±24.16 a)	174.79 ±24.97 a)	181.31 ±42.00 a) c)
	HT-S	181.48 ±10.43	227.09 ±27.17	311.96 ±193.20	259.43 ±32.53	230.07 ±24.88
IL-10 (pg/ml)	NT-T	57.94 ±37.82	65.35 ±42.25	64.56 ±41.83	64.55 ±37.31	59.50 ±30.24
	NT-S	76.54 ±38.79	82.69 ±47.93	77.45 ±45.21	76.22 ±32.22	78.58 ±41.04
	HT-T	37.99 ±38.90	46.19 ±25.87	50.41 ±33.99 a)	69.53 ±61.40 b)	72.37 ±69.29 b)
	HT-S	38.50 ±4.50 c)	70.28 ±15.6 b)	82.52 ±24.33 b)	98.65 ±38.27 b)	106.38 ±50.08 b)
HMGB1 (ng/ml)	NT-T	1.25 ±0.87	2.53 ±1.58 a) b)	2.20 ±1.54	4.80 ±3.94 a) b)	3.01 ±3.21
	NT-S	0.54 ±0.61	0.45 ±0.26	1.40 ±0.65	1.08 ±0.53	1.77 ±0.35
	HT-T	1.54 ±1.23	3.83 ±1.19 a) b)	3.70 ±2.56	4.81 ±2.49 a) b)	4.73 ±2.30 a) b) c)
	HT-S	1.78 ±0.88	1.73 ±0.49	1.63 ±1.33	1.22 ±0.91	1.46 ±1.17
HSP70 (ng/ml)	NT-T	87.75 ±59.08	54.21 ±45.71a) b)	47.04 ±40.07 a) b)	56.06 ±42.95 b)	75.96 ±59.36
	NT-S	129.92 ±47.00	131.04 ±33.52	110.19 ±34.71	83.89 ±19.63	79.14 ±36.73
	HT-T	50.74 ±39.73	31.95 ±37.48 b)	18.98 ±21.05 b) c)	16.03 ±14.53 b) c)	11.51 ±9.79 b) c)
	HT-S	53.37 ±32.71	54.95 ±40.98	49.92 ±39.50	42.27 ±39.79	32.63 ±34.96 b)