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. 2016 May 4;11(5):e0154375. doi: 10.1371/journal.pone.0154375

Fig 1. Pre-treatment with paeonol protected against APAP-induced liver injury.

Fig 1

Mice were administered with either vehicle (0.5% CMC-Na) or paeonol (25, 50, 100 mg/kg) by gavage for three days. At day 3, mice were intraperitoneally (i.p.) injected with either 400 mg/kg APAP or an equal volume of PBS. Liver tissues were collected after APAP administration for 6 h (A) and 24 h (B). Liver sections were stained with H&E. Magnification: 200X. (C) After APAP administration for 6 h, blood was collected and the levels of ALT and AST in the serum were determined by a commercially available kit. Data are shown as means ± S.E.M. *P<0.05, **P<0.01 v.s. APAP treatment (n = 8).