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. 2016 May 4;11(5):e0154880. doi: 10.1371/journal.pone.0154880

Table 2. Methodological differences in the PAS paradigm between the studies.

Study A & B C & D E F G H I
PAS 180 paired stimuli, interval of 5 s, interstimulus interval of 25 ms between electrical and magnetic stimulus 90 paired stimuli, interval of 20 s, ISI 25 ms between electrical and magnetic stimulus 132 paired stimuli, interval of 5 s, ISI 25 ms between electrical and magnetic stimulus 132 paired stimuli, interval of 5 s, ISI 25 ms between electrical and magnetic stimulus 132 paired stimuli, interval of 5 s, ISI 25 ms between electrical and magnetic stimulus 132 paired stimuli, interval of 5 s, ISI 25 ms between electrical and magnetic stimulus 132 paired stimuli, interval of 5 s, ISI 25 ms between electrical and magnetic stimulus
TMS TMS adjusted to 1 mV unconditioned MEP amplitude.20 MEPs per condition. Post measurements at 0, 8 and 15 minutes post intervention. TMS 0.5–1.0 mV interval 10 s, 20 MEPs per condition. Post measurements at 0, 15, 30 (60 min for study C) post intervention. TMS 0.5–1.0 mV; 10 MEPs per condition; post measurements at 0, 15, 30 post intervention. TMS 0.5–1.0 mV; 10 MEPs per condition; post measurements at 0, 15, 30 post intervention. TMS 0.5–1.0 mV; 10 MEPs per condition; post measurements at 0, 15, 30 post intervention. TMS 0.5–1.0 mV; 10 MEPs per condition; post measurements at 0, 15, 30 post intervention. TMS 0.5–1.0 mV; 10 MEPs per condition; post measurements at 0, 15, 30 post intervention.
E-Stim 300% of perception threshold at median nerve 300% perception threshold at ulnar nerve 300% of perception threshold at median nerve 300% perception threshold at median nerve (some participants did not tolerate stimulation at 300% perception threshold, there the stimulation intensity was adjusted individually (mean 273%), a visible twitch of the thumb was required) 300% of perception threshold at median nerve 300% of perception threshold at median nerve 300% perception threshold at median nerve (some participants did not tolerate stimulation at 300% perception threshold, there the stimulation intensity was adjusted individually (mean 277%), a visible twitch of the thumb was required)
Muscle APB (right Hand, only right handed subjects) ADM (dominant hand) APB (right Hand, only right handed subjects) APB (right Hand, only right handed subjects) APB (right Hand, only right handed subjects) APB (right Hand, only right handed subjects) APB (right Hand, only right handed subjects)
Other Neuronavigation, Attention monitored by counting visual stimuli Experiment conducted in the afternoon. Experiment conducted between 10 AM and 3 PM Attention monitored by counting number of ulnar nerve stimulations Experiment conducted between 9 AM and 6 PM Attention monitored by counting number of ulnar nerve stimulations Experiment conducted between 9 AM and 6 PM Attention monitored by counting number of median nerve stimulations Experiment conducted between 9 AM and 5 PM Attention monitored by counting number of ulnar nerve stimulations