Fig 7.

(A-D) Electron micrographs of asymmetric synapses labeled for CaMKII. Experimental conditions were as described in Fig 5. Label for CaMKII was dispersed in the postsynaptic cytoplasm under basal control conditions (A) or after zinc incubation (C), and the curvature of the PSD was typically flat. After NMDA (B) or zinc+NMDA (D) treatment, label for CaMKII was accumulated at the PSD, and the curvature of PSD was typically arched into the presynaptic terminal. Scale bar = 0.1 μm. (E) Bar graphs represent combined data from S6 Table. Zinc has no effect on the labeling intensity of CaMKII at the PSD either under basal conditions or upon treatment with NMDA.