Figure 2.

Telmisartan induces cell death of HTLV‐1‐associated cell lines. Cell lines were incubated at 2 × 10⁵ cells·mL⁻¹ in the presence of indicated concentrations of ARBs for 72 h. (A) Proliferation of cell lines in the absence or presence of indicated concentrations of telmisartan, irbesartan, or valsartan were assessed by WST‐8 assay. Cells cultured in the absence of telmisartan were assigned a relative viability of 1. Data represent mean ± SD of three independent experiments. Apoptotic cells were detected as annexin V‐positive cells (B) and TUNEL‐positive cells (C) using flow cytometry. Data represent mean percentage of apoptotic cells ± SD of three independent experiments.