Figure 3.

Telmisartan induces loss of mitochondrial transmembrane potential and ROS generation. S1T, MT‐2, Jurkat and HL60 cells were treated with telmisartan (100 μm) for 24 h. (A) Cells were analyzed for JC‐1 green and JC‐1 red fluorescence emission components by flow cytometry. (B) ROS levels were determined by assaying the fluorescent product, 5(6)‐carboxy‐2′,7′‐dichlorofluorescein, in viable cells by flow cytometry. Three independent experiments were performed per cell line, with representative results presented.