Figure 2.

Selective inhibition of the binding of Aβ oligomer to EphB2 by selected compounds. (A) Structures of the four selected compounds are shown. (B) The indicated concentration of each compound was added simultaneously with Aβ oligomers to EphB2‐coated wells, and the amount of bound biotin‐Aβ was determined. (C) Each compound (100 μm) or ICSM35 (2 μg·mL⁻¹) was added simultaneously with Aβ oligomer to PrP^C‐coated wells, and the amount of bound biotin‐Aβ was determined. Values represent the mean ± SD (n = 3). **P < 0.01. Basically similar results were obtained in another independent experiment.