Fig 5. Percentage of essential genes satisfying Achilles-based threshold of essentiality.

Percentage of essential genes obtained from the reconstructed context-specific networks of selected cancer cell lines using our algorithm under Schema 1, 2 and 3 that have a negative Achilles-based score, indicating a higher probability of being essential than non-essential according to processed gene silencing data obtained from project Achilles. The base network is Recon2. The last boxplot indicates this percentage when all the metabolic genes are taken into account.