Figure 3.
Proposed bile acid 7α-dehydroxylation pathway of cholic acid in Clostridium scindens. The multistep 7α-dehydroxylation pathway converts the primary bile acids cholic acid and chenodeoxycholic acid into the secondary bile acids deoxycholic acid and lithocholic acid, respectively. Abb. baiG, primary bile acid transporter; baiB, bile acid-coenzyme A ligase; baiA, 3α-hydroxysteroid dehydrogenase; baiCD, 7α-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductase; baiF, bile acid coenzyme A transferase/hydrolase; baiE, bile acid 7α-dehydratase.