A hypothetical model of host-pathogen interaction of S. suis in the gastro-intestinal tract. S. suis translocation model of host -intestinal mucosa. S. suis intestinal infection occurs with 2 different transmissions and circumstances in the 2 hosts as summarized in the table. S. suis isolates belong to clonal complex CC1 and CC20 of serotype 2 (SS2/CC1 and SS2/CC20), and clonal complex CC16 of serotype 9 (SS9/CC16) with low (+) medium (++), high (+++), adhesion and translocation ability, after 2-4 hours of co-incubation with host IEC. The description of interaction steps are found in the text. Sly, suilysin; Hyl, hyaluronidase; CPS, capsular polysaccharides; DCs dendritic cells, Mo/M Monocytes/Macrophages, IMLNs intestinal mesenteric lymph nodes.