Figure 1. Stat5b is required for immunological tolerance.
(A) Cartoon depicts the mutant mice used in this study. Genotypes are grouped according to total Stat5 alleles. (B) Bar graphs show averaged RBC, hematocrit and WBC counts. (C) Scatter plot shows kidney pathology scores. (D) Scatter plot shows urinary albumin/creatinine protein ratios. (E) Bar graph shows ELISA measurements (O.D.) for anti-double stranded DNA antibodies in serum. (F) Micrographs show representative H & E kidney sections (40X magnification). (B–E) Number of Stat5a, Stat5b and total Stat5 alleles (i.e. genotype) is explained in the key below each graph. Data are compiled from 3–5 mice per genotype. Error bars indicate standard deviation.