Table 2. Baseline characteristics stratified by age grouping and time period.
| Randomization Year | ||||
|---|---|---|---|---|
|
|
||||
| 1994–1997 | 1998–2001 | 2002–2005 | 2006–2010 | |
| Age <65 years | (N=13401) | (N=6377) | (N=4320) | (N=11774) |
|
| ||||
| Demographics | ||||
| Age, median (Q1-Q3) | 56 (49-60) | 55 (50-60) | 59 (52-62) | 58 (53-61) |
| Female sex | 27.1% (13401)* | 28.8% (6377) | 24.8% (4320) | 23.3% (11774) |
| White race | 87.3% (13236) | 91.5% (6376) | 83.4% (4226) | 84.0% (11378) |
| Past medical history | ||||
| Diabetes | 17.8% (13401) | 17.9% (6377) | 27.0% (4320) | 33.1% (11774) |
| Hypertension | 47.8% (13401) | 47.4% (6377) | 59.7% (4320) | 66.4% (11774) |
| Hypercholesterolemia | 46.5% (13401) | 43.0% (6377) | 59.3% (4320) | 60.1% (11774) |
| Chronic renal insufficiency | 0.5% (13401) | 0.7% (2709) | 5.5% (8566) | |
| Current smoking | 40.8% (13381) | 41.4% (6377) | 42.8% (4320) | 39.5% (11774) |
| Congestive heart failure | 6.0% (13401) | 5.4% (6377) | 6.3% (4320) | 11.2% (11774) |
| MI | 32.0% (13401) | 25.2% (6377) | 23.8% (4320) | 32.2% (11774) |
| PCI | 13.0% (13401) | 12.5% (6377) | 18.5% (4320) | 25.0% (11774) |
| CABG | 11.6% (13401) | 9.7% (6377) | 12.5% (4320) | 9.5% (11774) |
| PVD | 6.5% (13401) | 4.7% (2924) | 6.3% (4320) | 9.0% (11774) |
| Presenting clinical characteristics | ||||
| GRACE score risk for 6-month mortality, median (Q1-Q3)† | 85 (71-98) | 82 (67-95) | 96 (87-106) | 91 (81-101) |
| GRACE risk score for 6-month mortality ≥140† | 0.3% (10331) | 1.0% (2861) | 0.7% (4255) | 0.5% (9493) |
|
| ||||
| Age 65–74 years | (N=8710) | (N=4353) | (N=4014) | (N=8170) |
|
| ||||
| Demographics | ||||
| Age, median (Q1-Q3) | 70 (67-72) | 70 (67-72) | 70 (67-72) | 69 (67-72) |
| Female sex | 37.9% (8710) | 38.9% (4353) | 35.3% (4014) | 33.0% (8170) |
| White race | 92.9% (8649) | 94.9% (4352) | 88.8% (3965) | 87.7% (7946) |
| Past medical history | ||||
| Diabetes | 24.8% (8710) | 26.1% (4353) | 32.6% (4014) | 35.9% (8170) |
| Hypertension | 56.7% (8710) | 59.6% (4353) | 72.8% (4014) | 75.8% (8170) |
| Hypercholesterolemia | 42.4% (8710) | 41.2% (4353) | 62.2% (4014) | 61.6% (8170) |
| Chronic renal insufficiency | 1.2% (8710) | 2.2% (1586) | 11.4% (5654) | |
| Current smoking | 16.6% (8696) | 15.9% (4353) | 17.2% (4014) | 17.1% (8170) |
| Congestive heart failure | 11.1% (8710) | 9.9% (4353) | 10.2% (4014) | 14.5% (8170) |
| MI | 37.6% (8710) | 33.4% (4353) | 30.5% (4014) | 29.0% (8170) |
| PCI | 11.9% (8710) | 12.1% (4353) | 22.9% (4014) | 24.0% (8170) |
| CABG | 15.2% (8710) | 12.5% (4353) | 18.7% (4014) | 13.6% (8170) |
| PVD | 12.0% (8710) | 11.2% (1776) | 11.5% (4014) | 10.5% (8170) |
| Presenting clinical characteristics | ||||
| GRACE score risk for 6-month mortality, median (Q1-Q3)† | 114 (102-124) | 111 (99-124) | 116 (106-127) | 112 (103-123) |
| GRACE risk score for 6-month mortality ≥140† | 6.1% (6885) | 6.8% (1729) | 7.1% (3956) | 4.7% (6204) |
|
| ||||
| Age 75–79 years | (N=2543) | (N=1769) | (N=1611) | (N=2911) |
|
| ||||
| Demographics | ||||
| Age, median (Q1-Q3) | 77 (76-78) | 77 (76-78) | 77 (76-78) | 77 (76-78) |
| Female sex | 44.4% (2543) | 46.7% (1769) | 41.4% (1611) | 38.9% (2911) |
| White race | 94.2% (2528) | 97.2% (1768) | 90.8% (1594) | 90.0% (2833) |
| Past medical history | ||||
| Diabetes | 25.0% (2543) | 27.1% (1769) | 32.2% (1611) | 34.4% (2911) |
| Hypertension | 57.8% (2543) | 64.0% (1769) | 76.8% (1611) | 81.0% (2911) |
| Hypercholesterolemia | 35.4% (2543) | 35.8% (1769) | 59.0% (1611) | 59.4% (2911) |
| Chronic renal insufficiency | 2.2% (2543) | 2.6% (568) | 15.2% (1829) | |
| Current smoking | 9.0% (2542) | 6.8% (1769) | 9.6% (1611) | 8.5% (2911) |
| Congestive heart failure | 16.0% (2543) | 13.8% (1769) | 13.2% (1611) | 17.2% (2911) |
| MI | 37.4% (2543) | 36.2% (1769) | 30.4% (1611) | 32.9% (2911) |
| PCI | 9.4% (2543) | 12.2% (1769) | 22.7% (1611) | 24.3% (2911) |
| CABG | 13.4% (2543) | 13.1% (1769) | 20.7% (1611) | 15.4% (2911) |
| PVD | 13.5% (2543) | 13.7% (657) | 12.0% (1611) | 11.6% (2911) |
| Presenting clinical characteristics | ||||
| GRACE score risk for 6-month mortality, median (Q1-Q3)† | 130 (118-141) | 125 (115-141) | 130 (121-142) | 128 (118-138) |
| GRACE score ≥140† | 29.0% (1998) | 26.4% (640) | 30.6% (1584) | 21.4% (2313) |
|
| ||||
| Age 80–84 years | (N=1277) | (N=778) | (N=888) | (N=1603) |
|
| ||||
| Demographics | ||||
| Age, median (Q1-Q3) | 82 (81-83) | 82 (80-83) | 82 (80-83) | 82 (81-83) |
| Female sex | 50.0% (1277) | 50.6% (778) | 45.7% (888) | 47.1% (1603) |
| White race | 95.4% (1275) | 96.5% (778) | 90.6% (883) | 91.8% (1566) |
| Past medical history | ||||
| Diabetes | 21.5% (1277) | 24.8% (778) | 28.2% (888) | 32.5% (1603) |
| Hypertension | 57.0% (1277) | 57.1% (778) | 76.4% (888) | 82.5% (1603) |
| Hypercholesterolemia | 27.1% (1277) | 29.6% (778) | 53.3% (888) | 58.2% (1603) |
| Chronic renal insufficiency | 3.1% (1277) | 4.2% (263) | 21.3% (993) | |
| Current smoking | 6.3% (1275) | 4.8% (778) | 6.0% (888) | 5.9% (1603) |
| Congestive heart failure | 21.8% (1277) | 18.1% (778) | 17.5% (888) | 19.9% (1603) |
| MI | 41.6% (1277) | 42.5% (778) | 30.9% (888) | 32.8% (1603) |
| PCI | 6.6% (1277) | 11.2% (778) | 21.8% (888) | 23.6% (1603) |
| CABG | 9.0% (1277) | 10.7% (778) | 18.7% (888) | 16.2% (1603) |
| PVD | 14.8% (1277) | 12.3% (326) | 15.2% (888) | 11.2% (1603) |
| Presenting clinical characteristics | ||||
| GRACE score risk for 6-month mortality, median (Q1-Q3)† | 141 (130-153) | 138 (127-150) | 140 (129-151) | 137 (128-148) |
| GRACE score ≥140† | 52.7% (1017) | 44.1% (322) | 51.3% (875) | 43.4% (1237) |
|
| ||||
| Age ≥85 years | (N=447) | (N=326) | (N=341) | (N=528) |
|
| ||||
| Demographics | ||||
| Age, median (Q1-Q3) | 87 (86-88) | 86 (85-88) | 87 (86-89) | 86 (86-88) |
| Female sex | 57.3% (447) | 54.6% (326) | 47.2% (341) | 45.8% (528) |
| White race | 95.0% (443) | 97.2% (326) | 92.9% (338) | 93.0% (513) |
| Past medical history | ||||
| Diabetes | 16.8% (447) | 23.6% (326) | 23.2% (341) | 29.4% (528) |
| Hypertension | 55.0% (447) | 60.7% (326) | 75.1% (341) | 81.3% (528) |
| Hypercholesterolemia | 23.3% (447) | 21.8% (326) | 49.6% (341) | 55.3% (528) |
| Chronic renal insufficiency | 3.8% (447) | 5.1% (99) | 26.6% (316) | |
| Current smoking | 4.9% (446) | 2.8% (326) | 5.6% (341) | 3.2% (528) |
| Congestive heart failure | 21.5% (447) | 23.0% (326) | 19.1% (341) | 24.6% (528) |
| MI | 41.8% (447) | 40.8% (326) | 34.0% (341) | 35.8% (528) |
| PCI | 5.8% (447) | 8.0% (326) | 18.2% (341) | 21.0% (528) |
| CABG | 8.3% (447) | 8.3% (326) | 19.4% (341) | 17.0% (528) |
| PVD | 13.9% (447) | 14.2% (120) | 13.2% (341) | 12.5% (528) |
| Presenting clinical characteristics | ||||
| GRACE score risk for 6-month mortality, median (Q1-Q3)† | 151 (139-165) | 147 (134-159) | 151 (141-165) | 148 (138-157) |
| GRACE score ≥140† | 74.3% (366) | 68.9% (119) | 77.7% (336) | 70.0% (387) |
*
Percentage and denominator for each variable across time is reported.
†
GRACE score for 6-month death is not available for
GUSTO IV, PRISM, PRISM PLUS and APPRAISE-2. CABG: coronary artery bypass graft, MI: myocardial infarction, PCI: percutaneous coronary intervention, Q1-Q3: first and third quartiles.