Table 4. Clinical outcomes by age according to randomization year.
| Randomization Year | ||||
|---|---|---|---|---|
|
|
||||
| 1994–1997 | 1998–2001 | 2002–2005 | 2006–2010 | |
| Age <65 years | (N=13401) | (N=6377) | (N=4320) | (N=11774) |
|
| ||||
| Death* | ||||
| In-hospital death | 1.3% (13401) | 0.9% (6377) | 0.9% (4318) | 0.8% (11758) |
| 30-day death | 1.6% (13401) | 1.4% (6377) | 1.2% (4320) | 0.9% (11774) |
| Kaplan-Meier rates† | ||||
| 6-month death | 331 (3.0%) | 82 (2.8%) | 108 (2.5%) | 212 (1.9%) |
| 6-month death among patients with GRACE score available‡ | 293 (2.9%) | 81 (2.9%) | 108 (2.5%) | 165 (1.8%) |
| 1-year death | 351 (3.8%) | 98 (3.6%) | 144 (3.4%) | 298 (2.7%) |
|
| ||||
| Age 65–74 years | (N=8710) | (N=4353) | (N=4014) | (N=8170) |
|
| ||||
| Death* | ||||
| In-hospital death | 3.8% (8709) | 3.3% (4353) | 2.4% (4012) | 1.5% (8157) |
| 30-day death | 4.3% (8710) | 3.9% (4353) | 2.7% (4014) | 1.7% (8170) |
| Kaplan-Meier rates† | ||||
| 6-month death | 557 (7.5%) | 105 (6.0%) | 214 (5.3%) | 269 (3.4%) |
| 6-month death among patients with GRACE score available‡ | 495 (7.2%) | 102 (5.9%) | 210 (5.3%) | 208 (3.4%) |
| 1-year death | 581 (9.2%) | 129 (7.8%) | 291 (7.3%) | 371 (5.0%) |
|
| ||||
| Age 75–79 years | (N=2543) | (N=1769) | (N=1611) | (N=2911) |
|
| ||||
| Death* | ||||
| In-hospital death | 6.8% (2542) | 5.5% (1769) | 4.0% (1611) | 2.8% (2903) |
| 30-day death | 7.7% (2542) | 6.3% (1769) | 5.0% (1611) | 3.2% (2911) |
| Kaplan-Meier rates† | ||||
| 6-month death | 284 (13.0%) | 62 (9.5%) | 138 (8.6%) | 180 (6.5%) |
| 6-month death among patients with GRACE score available‡ | 242 (12.2%) | 61 (9.6%) | 133 (8.4%) | 152 (6.7%) |
| 1-year death | 278 (14.6%) | 72 (11.6%) | 180 (11.2%) | 231 (8.6%) |
|
| ||||
| Age 80–84 years | (N=1277) | (N=778) | (N=888) | (N=1603) |
|
| ||||
| Death* | ||||
| In-hospital death | 8.1% (1277) | 8.1% (778) | 5.4% (888) | 3.8% (1593) |
| 30-day death | 8.9% (1277) | 9.5% (778) | 6.3% (888) | 3.4% (1603) |
| Kaplan-Meier rates† | ||||
| 6-month death | 194 (17.6%) | 42 (12.9%) | 91 (10.3%) | 125 (8.2%) |
| 6-month death among patients with GRACE score available‡ | 172 (17.0%) | 40 (12.5%) | 89 (10.2%) | 101 (8.3%) |
| 1-year death | 204 (21.1%) | 54 (18.2%) | 128 (14.5%) | 176 (12.1%) |
|
| ||||
| Age ≥85 years | (N=447) | (N=326) | (N=341) | (N=528) |
|
| ||||
| Death* | ||||
| In-hospital death | 11.2% (447) | 8.9% (326) | 8.2% (341) | 5.5% (523) |
| 30-day death | 13.0% (447) | 11.7% (326) | 11.1% (341) | 5.1% (528) |
| Kaplan-Meier rates† | ||||
| 6-month death | 98 (24.8%) | 21 (17.6%) | 60 (17.6%) | 63 (12.6%) |
| 6-month death among patients with GRACE score available‡ | 84 (23.1%) | 21 (17.7%) | 59 (17.6%) | 49 (13.1%) |
| 1-year death | 94 (26.5%) | 29 (26.6%) | 83 (24.4%) | 88 (18.8%) |
*
Percentage and denominator for in-hospital and 1-month mortality across time is reported.
†
Kaplan-Meier rates are reported for 6-month and 1-year mortality outcomes, as 6-month follow-up is not complete in GUSTO IV and PRISM and 1-year mortality is not complete in GUSTO IV, PRISM, and PRISM PLUS.
‡
GRACE score was not available in GUSTO IV, PRISM, PRISM PLUS, and APPRAISE-2.