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. Author manuscript; available in PMC: 2017 May 4.
Published in final edited form as: Nat Prod Rep. 2016 May 4;33(5):595–601. doi: 10.1039/c5np00153f

Fig. 1. Discovery of cyclopamine as a plant-derived teratogen.

Fig. 1

(A) Lamb with cyclopia and other craniofacial defects resulting from maternal ingestion of V. californicum. (B) Alpine meadow containing patches of V. californicum. Reproduced with permission (Ref. 5, copyright 2006, John Wiley and Sons). (C) Structures of teratogenic steroid alkaloids isolated from V. californicum (atomic numbering system shown).