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. Author manuscript; available in PMC: 2017 May 4.
Published in final edited form as: Nat Prod Rep. 2016 May 4;33(5):595–601. doi: 10.1039/c5np00153f

Fig. 2. Cyclopamine inhibits Hh signal transduction.

Fig. 2

(A) The Hh signalling pathway with positive and negative regulators shown in green and red, respectively. (B) Comparison of wild type and Shh knockout mouse embryos (E11.5 stage). Adapted with permission (Ref. 19, copyright 1996, Nature Publishing Group). (C) Diagram of the chick neural tube prior to dorsal closure (transverse cross section) and micrographs of midline explants treated with either a vehicle control or jervine and then immunostained for SHH-dependent neuronal fates (floor plate cells, HNF3β; motor neurons, Isl1). Adapted with permission (Ref. 20, copyright 1998, The American Association for the Advancement of Science).