Table 3.

The genetic diversity among alphacoronavirus genotypes in the spike gene

	HCoV	Genetic distance
NL63		genotype A	genotype B	genotype C
	genotype A	-	0.8†	0.5
	genotype B	7.6*	-	0.6
	genotype C	2.1	6.7	-
229E		group 1	group 2	group 3	group 4
	group 1	-	0.4	0.6	0.7
	group 2	1.5	-	0.3	0.4
	group 3	2.5	1.2	-	0.3
	group 4	3.5	2.6	1.5	-

^*Pairwise genetic distances are expressed in percentage (%) of nucleotide difference.

^†Standard error estimates of the mean genetic distances are shown in the upper diagonal.