Table 1.

Selected published literature related to persistent symptoms of illness following symptomatic DENV infection that may result in loss of productivity (asthenia, fatigue, trouble working)

Author	Country	Dengue definition	Follow-up	Sample size	Participants' age (years)	Prevalence of symptoms	RF and comments†
Teixeira and others13	Brazil	Clinically defined (86.5% laboratory confirmed)	2 weeks, 2 months, 6 months, 1 and 2 years	118	> 18	57%, 12%, and 5% reported difficulty to work at 2 weeks, 2 months, and 6 months, respectively	RF: female, age > 50 years. 65% reported symptoms at 2 weeks; 8.5% at 30 days.
Tristao and others14	Brazil	Laboratory confirmed	8, 15, 30, and 60 days	110 (90 DENV)	> 18	62%, 47%, 31%, and 20% at 8, 15, 30, and 60 days, respectively	No significant difference in persistence of symptoms by severity of illness
Dettogni and others16	Brazil	Laboratory confirmed	15, 30, 60 days	96	> 18	41%, 17%, and 5% at 15, 30, and 60 days, respectively	RF: female, secondary DENV infection
Del Valle and others17	Cuba	Laboratory-confirmed DHF	Monthly for 1 year	37	All ages, (62%: 15–34)	32%, 8%, and 5%, at 1, 2, and 3 months, respectively	Patients in sample had liver dysfunction from DENV
Garcia and others11	Cuba	Laboratory confirmed and asymptomatic (AD)	2 years	139	31–60	23% of symptomatic; 0% of AD	RF: female. No significant difference between severity and symptom persistence
Gonzalez and others12	Cuba	Laboratory-confirmed DHF/DSS	1, 2, 3, 4 weeks; 6 months	47	16–64	68%, 53%, 40%, 36%; and 27% at 1, 2, 3, 4 weeks and 6 months, respectively	Symptoms had irregular appearance, related to mental and physical activity
Lopez and others18	Cuba	Laboratory confirmed	1 year	28	18–48	36%, 11%, and 7% at 2 weeks, 6 months, and 12 months, respectively	Sample included only pregnant women
Halsey and others15	Peru	Laboratory confirmed	10–60 days	9,067 (3,659 DENV)	> 5	4%, 2%, and 2% at 10–20, 21–30, and 31–60 days, respectively	RF: older age and female gender. Passive follow-up, conservative estimates
Low and others19	Singapore	Laboratory confirmed	3 weeks	454 (133 DENV)	> 21	7%*	RT-PCR negative patients used as controls
Seet and others7	Singapore	Laboratory confirmed	2 months	127	16–70	24%	RF: older age, female, chills. Severity not significantly associated to fatigue

AD = asymptomatic dengue infection; DENV = dengue virus; DF = dengue fever; DHF = dengue hemorrhagic fever; DSS = dengue shock syndrome; RF = risk factors; RT-PCR = reverse transcriptase-polymerase chain reaction.

^*9.3% of patients presented with persistent symptoms after 3 weeks; of these, 72.7% reported fatigue.

^†RFs relate to the patient showing any type of persistent symptom following a dengue episode. RFs are not necessarily associated to productivity loss.