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. 2016 May 4;94(5):993–1001. doi: 10.4269/ajtmh.15-0665

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©The American Society of Tropical Medicine and Hygiene

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Figure 1. — Study design for “natural aging” of ACTs. Herein, 2,880 tablets each of Coartem^® AM/LUM and Winthrop^® AS/AQ were stored for 36 months in two sites, Ghana (KHRC) and a stability chamber in London (LSHTM), in the presence and absence of light and with intact or perforated blister packs. Temperature and humidity settings in the stability chamber were adjusted on a monthly basis to the average ambient conditions in Ghana (33°C ± 5°C, relative humidity = 55% ± 20%). ACTs = artemisinin-based combination therapies; AM/LUM = artemether/lumefantrine; AS/AQ = artesunate/amodiaquine; KHRC = Kintampo Health Research Center.