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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 18;26(9):2188–2193. doi: 10.1016/j.bmcl.2016.03.066

Scheme 1.

Scheme 1

General synthesis of quinoxaline 1,4-di-N-oxide derivatives.

Reagents and conditions: (i) N,N-DMF, NaOCl, low temperature; (ii) ethanolamine, CaCl2; (iii) microwave assisted synthesis; (iv) NaOH, MeOH, ice bath; (v) NaOH, MeOH, freezing bath; (vi) N,N-DMF, reflux; (vii) CH3CN, Et3N, rt.; (viii) CH3CN, DBU, 50°C.