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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 18;26(9):2188–2193. doi: 10.1016/j.bmcl.2016.03.066

Table 2.

Minimum inhibitory concentration against single-drug resistant strains of M. Tb.

Code Structure H37Rv INH-R M. Tb. RIF-R M. Tb. OFX-R M. Tb.
SRI 1345 strain SRI 1369 strain SRI 1367 strain SRI 4000 strain
MIC μg/mL % Inh(a) MIC μg/mL % Inh. R(b) MIC μg/mL % Inh. R(b) MIC μg/mL % Inh. R(b)
3 graphic file with name nihms-773123-t0004.jpg 2 80 1 64 2 0.5 51 4 0.5 100 4
16 graphic file with name nihms-773123-t0005.jpg 2 61 0.5 78 4 0.5 66 4 0.25 76 8
18 graphic file with name nihms-773123-t0006.jpg 1 78 0.25 57 8 0.25 68 8 0.25 84 8
21 graphic file with name nihms-773123-t0007.jpg 1.5 78 0.19 51 8 0.19 73 8 0.19 81 8
24 graphic file with name nihms-773123-t0008.jpg 0.75 51 0.75 89 1 0.38 75 2 0.19 62 4
RIF 0.05 55 0.05 72 0.195 53
INH 0.02 55
a

Percentage inhibition at the MIC concentration.

R: Ratio of MIC H37Rv/MIC Resistant-strain

INR-R: isoniazid-resistant

RIF-R: rifampin-resistant

OFX-R: ofioxacin-resistant