. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 18;26(9):2188–2193. doi: 10.1016/j.bmcl.2016.03.066

Table 4.

Intracellular activity in M. tb infected J774 macrophages.

Code	Log reduction^a			% of cellular viability
Code	Low conc^b	Mid conc^b	High conc^b	Low conc^b	Mid conc^b	High conc^b
3	2.11	1.68	1.76	70	81	26
16	1.68	1.57	2.67	88	37	37
18	1.74	1.5	2.66	83	53	65
21	1.43	1.41	3.86	60	64	47
24	2.17	1.66	1.76	70	81	26
RIF	0.48	1.73	2.68	93	87	80

Intracellular drug activity is reported as log reduction values calculated as reduction in Mtb concentration from zero hour to 7 days post-infection.

The three concentrations chosen were based on the MIC data generated in the HTS primary screen. The mid concentration bracketed the reported MIC with the lower concentration ten-fold below the mid and the higher concentration ten-fold above the mid.