Fig. 4.

Combination indexes of propranolol with chemotherapy agents. Dot plot representation of the combination index of propranolol in association with doxorubicin, paclitaxel and vinblastine on BMST (□) and BMST-Ras (○) cell lines. Growth inhibition assays were performed using Alamar Blue after 72 h incubation with a range of chemotherapeutic drug concentrations in the presence or absence of propranolol at 50 μM. CI values were determined based on the Chou and Talalay method for all tested concentrations of chemotherapeutic drug. Bars, mean of at least three individual experiments; y axis, log scale.