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Observed versus the IV estimated association of T2D with decreased eGFR and increased uACR. In the MR framework, T2D_GRS-T2D association is assumed to be independent of confounders. All the analyses were adjusted for age (years), sex, BMI (kg/m2), current smoking (yes or no), current drinking (yes or no), physical activity (mild, moderate or vigorous), hypertension (yes or no), total cholesterol (mmol/l), HDL-cholesterol (mmol/l), LDL-cholesterol (mmol/l) and triglycerides (mmol/l).
