Table 1.
MIC values (μg/mL) of antibiotics in the absence and presence of coumarin derivatives against S. aureus strains: SA-1199B (NorA), RN4220 (MsrA), and IS-58 (TetK).
| Antibiotic + coumarin | MIC (μg/mL) | ||
|---|---|---|---|
| IS-58 (TetK) Tetracycline |
RN4220 (MrsA) Erythromycin |
SA-1199B (NorA) Norfloxacin |
|
| Antibiotics alone | 64 | >256 | 128 |
| Antibiotics + 1 | 64 | >256 | 64 (2x) |
| Antibiotics + 11 | 64 | >256 | 32 (4x) |
| Antibiotics + 13 | 64 | >256 | 32 (4x) |
| Antibiotics + 16 | 64 | >256 | 16 (8x) |
| Antibiotics + 17 | 32 (2x) | >256 | 64 (2x) |
| Antibiotics + 18 | 32 (2x) | >256 | 64 (2x) |
| Antibiotics + 19 | 64 | >256 | 64 (2x) |