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. 2016 Mar 8;6:114–125. doi: 10.1016/j.ebiom.2016.03.006

Fig. 6.

Fig. 6

Early changes of the DOWN-genomic score as an independent prognostic factor. A) Receiver Operator Characteristic curves of the change of the DOWN genomic score and of procalcitonin (PCT) within the first 24 h for the prediction of mortality. Areas under the curve (AUCs) and p-values for the ROC analysis are provided. B) Comparative ROCs of the DOWN score with the presence of infection and with the presence of organ failure to predict mortality. AUCs and p-values for the ROC analysis are provided. C) Survival of patients enrolled in the confirmation cohort from Germany are divided into subgroups with and without early decrease of the down-genomic score by 17%. Those with less than 17% early decrease have prolonged survival. D) The prognostic value of this early decrease of the down-genomic score is confirmed in an independent cohort from Greece. p values of the log-rank tests are provided.