Table 1.
Characteristics of the seven genes used for the generation of the genomic score.
| Gene | Description | Function | Implicated pathway | Expression in severe inflammation |
|---|---|---|---|---|
| TLR 5 | Toll-like receptor 5 (flagellin) | Pathogen recognition | Toll-like receptor signaling | Up-regulation |
| CD59 | Protectin | Complement regulatory protein | Fcy receptor mediated phagocytosis | Up-regulation |
| CLU | Clusterin | Complement lysis inhibitor | Integrin signaling | Up-regulation |
| FGL2 | Fibrinogen-like 2 | Immune regulator, prothrombinase | Nur77 signaling in T lymphocytes | Down-regulation |
| IL7R | Interleukin-7 receptor | Lymphocyte development | CD28 signaling in T helper cells | Down-regulation |
| HLA-DPA1 | Major histocompatibility complex class II, DP alpha1 | Antigen presentation | Allograft rejection signaling | Down-regulation |
| CPVL | Carboxypeptidase, vitellogenic-like | Macrophages, inflammatory protease cascade, phagocytosis | Calcium-induced T lymphocyte apoptosis | Down-regulation |