Table 3.
Classification of German cohort into subgroups with and without early decrease of the down-genomic score by 17% in relation to 100-day mortality.
| Non-survivors | Survivors | Total | |||
|---|---|---|---|---|---|
| GES DOWN | Decrease ≤ 17% | 36 (21%) | 80 (47%) | 116 (67%) | PPV = 31% (23.3–39.9%) |
| Decrease > 17% | 9 (5%) | 47 (27%) | 56 (33%) | NPV = 84% (72.2–91.3%) |
|
| Total | 45 (26%) | 127 (74%) | 172 (100%) | ||
| Sensitivity = 80% (66.2–89.1%) |
Specificity = 37% (29.1–45.7%) |
||||
The threshold, adjusted to the sensitivity of 80% to predict a mortality, finally resulted in the negative predictive value NPV = 84%. The adjustment was at expense of specificity (37%) and positive predictive value (PPV = 31%). Analysis involved 172 of the initially enrolled patients because 24 patients were discharged from ICU or died before the second sampling.