Fig. 7.

Liver of SDD treated rats showing (a) Marked granular and vacuolar degeneration of the hepatocytes. (b) Hepatocellular necrosis; some appear with pyknotic nuclei and others without any nuclear structure (arrow), notice the appearance of apoptotic cells (arrow head). (c–f) Portal triads showing (c) marked bile duct hyperplasia with multiple newly formed bile ducteols (arrow). (d) Oval cell hyperplasia (O). (e) Moderate periductal fibroplasia, marked edema and thickening and hyalinization (H) of the blood vessel wall. (f) Marked periductul fibroplasia (F) with Azan stain.