Table 2.

In-vitro diffusion kinetics, EE and VS of TH released from ethosomes.

Formulation code	Drug entrapment efficiency (%) ± S.D	Zeta potential (mV)	Vesicle size (nm)	PI	Zero order	First order	Higuchi model	Korsmeyer Peppas model
					R2	R2	R2	n	k
F1	60.59 ± 1.92	−7.10 ± 0.51	712 ± 1.32	0.317 ± 0.01	0.998	0.882	0.892	0.621	1.301
F2	62.61 ± 2.13	−7.21 ± 0.16	681 ± 1.56	0.216 ± 0.02	0.997	0.809	0.893	0.711	1.457
F3	55.33 ± 1.32	−7.19 ± 0.18	539 ± 1.41	0.208 ± 0.01	0.999	0.770	0.908	0.786	1.605
F4	63.38 ± 1.18	−7.16 ± 0.22	812 ± 2.21	0.389 ± 0.03	0.995	0.845	0.916	0.636	1.354
F5	66.83 ± 1.52	−7.61 ± 0.38	332 ± 1.12	0.214 ± 0.02	0.997	0.767	0.889	0.791	1.582
F6	69.11 ± 2.11	−7.96 ± 0.65	248 ± 1.02	0.206 ± 0.10	0.999	0.732	0.928	0.812	1.669
F7	56.83 ± 1.09	−7.41 ± 0.46	227 ± 1.11	0.212 ± 0.04	0.997	0.685	0.947	0.793	1.585
F8	63.21 ± 2.62	−7.13 ± 0.25	695 ± 1.25	0.312 ± 0.02	0.998	0.800	0.908	0.652	1.398