Table 2.

Frequencies of Protein Expression in Particular CTC Groups

		CTC EP			CTC EMT			CTC Any
Protein Expression		Negative N (%)	Positive N (%)	P Value	Negative N (%)	Positive N (%)	P Value	Negative N (%)	Positive N (%)	P Value
APC	Negative	77 (46.7)	9 (52.9)	.622	76 (48.1)	8 (27.6)	.041	71 (48.6)	15 (34.9)	.112
Positive	88 (53.3)	8 (47.1)		82 (51.9)	21 (72.4)		75 (51.4)	28 (65.1)
ADAM23	Negative	40 (24.2)	6 (35.3)	.318	39 (24.8)	8 (26.7)	.833	34 (23.4)	13 (29.5)	.412
Positive	125 (75.8)	11 (64.7)		118 (75.2)	22 (73.3)		111 (76.6)	31 (70.5)
CXCL12	Negative	39 (23.5)	3 (17.6)	.585	40 (25.2)	3 (10.3)	.081	40 (27.2)	5 (11.6)	.035
Positive	127 (76.5)	14 (82.4)		119 (74.8)	26 (89.7)		107 (72.8)	38 (88.4)
E-cadherin	Negative	59 (39.9)	11 (64.7)	.050	61 (42.4)	11 (42.3)	.996	53 (40.2)	21 (52.5)	.167
Positive	89 (60.1)	6 (35.3)		83 (57.6)	15 (57.7)		79 (59.8)	19 (47.5)
RASSF1*	Negative	20 (31.7)	3 (27.3)	.767	23 (32.4)	1 (12.5)	.246	20 (31.3)	4 (23.5)	.535
Positive	43 (68.3)	8 (72.7)		48 (67.6)	7 (87.5)		44 (68.8)	13 (76.5)
SYK	Negative	63 (38.0)	5 (29.4)	.488	58 (36.7)	12 (40.0)	.732	54 (37.0)	16 (36.4)	.940
Positive	103 (62.0)	12 (70.6)		100 (63.3)	18 (60.0)		92 (63.0)	28 (63.6)
TIMP3	Negative	79 (48.2)	12 (75.0)	.040	80 (51.3)	13 (44.8)	.523	71 (49.0)	23 (54.8)	.508
Positive	85 (51.8)	4 (25.0)		76 (48.7)	16 (55.2)		74 (51.0)	19 (45.2)
BRMS1	Negative	11 (6.7)	2 (11.8)	.447	14 (9.0)	2 (6.9)	.715	12 (8.3)	4 (9.3)	.842
Positive	152 (93.3)	15 (88.2)		142 (91.0)	27 (93.1)		132 (91.7)	39 (90.7)
SOCS1	Negative	5 (3.0)	6 (35.3)	< .001	11 (7.0)	1 (3.4)	.478	5 (3.4)	7 (16.3)	.002
Positive	160 (97.0)	11 (64.7)		147 (93.0)	28 (96.6)		141 (96.6)	36 (83.7)

Number of samples analyzed in the study was n = 203; only successfully analyzed samples were included in the table.

^*For RASSF1, protein analyses were performed on 61 samples only because of the lack of material (tumor tissue).