Table 2. Regions with Altered Connectivity with the Right Inferior Frontal Gyrus Seed Region (Controls vs Patients and Atomoxetine versus Placebo).

	Coordinates	Z-score	Cluster size (voxels)
Region with reduced connectivity in Parkinson's disease
Left IFG/dorsolateral prefrontal cortex	−44 6 24	4.73	2669
Dorsal anterior cingulate	10 42 32	3.68*	48
Pre-SMA	−10 2 56	3.85*	217
Cerebellum	−10 −54 −8	5.22	3376
Region with increased connectivity on atomoxetine
Dorsal anterior cingulate (main effect of drug)	12 34 18	4.73	416
Left dorsolateral prefrontal cortex (drug interaction with fluency)	−50 20 34	3.98*	52

Abbreviations: DARTEL, Diffeomorphic Anatomical Registration Through Exponentiated L; IFG, inferior frontal gyrus; MNI, Montreal Neurological Institute; SMA, supplementary motor area.

Results are reported at whole brain family-wise error correction p<0.05, or as indicated by asterisk also at the exploratory threshold uncorrected p<0.001. Coordinates refer to the local peak in MNI space using a normalized study-specific template (DARTEL).