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Compared with diabetic rats, four-week 100 mg/kg of metformin (Met) and Lycium barbarum polysaccharide (LBPS) at doses of 100, 250, and 500 mg/kg positively regulated the abnormal changes on (a) fasting plasma glucose level and (b) serum insulin concentration. Data are expressed as mean ± SD (n = 8) and analyzed by using a one-way ANOVA. # P < 0.05 and ## P < 0.01 versus normal controls; ∗ P < 0.05 and ∗∗ P < 0.01 versus diabetic model rats.
