Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 15;44(8):3567–3585. doi: 10.1093/nar/gkv1475

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 7. — Ets1-promoted lineage commitment by dynamic co-association and chromatin remodeling. Model summing up transactivation mechanics of class 1 (DN-specific), 4 (DN-DP shared) and 5 (DP-specific) Ets1 targets. For class 1, Ets1 binds to NORs in DN, recruiting E2A, Runx1 partners and Pol II, leading to downstream activation of DN-specific, early hematopoietic genes. eRNA is produced, however at modest quantities. These sites are lost in DP. For class 4, Ets1 binds to NORs in DN, recruiting E2A, Runx1 partners and Pol II, transactivating general hematopoietic genes. High quantities of eRNA are produced. These sites are maintained and nucleosome-free in DP, with E2A being lost. In class 5 sites, these sites are nucleosome-occupied and devoid of TFs in DN, with the nearest gene being repressed. In DP, Ets1 binds as a homodimer, opens up the chromatin, recruiting TCF1 and Pol II, resulting in upregulation of DP/T-cell lineage-specific genes, as well as high eRNA production.