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. 2016 Jan 26;44(8):e77. doi: 10.1093/nar/gkw022

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Alvis visualizes an alignment of 1224 mammalian nucleotidyl cyclases. Sequences containing Glu in position 146 are selected (red). None of these sequences contain Asp within the functionally correlated site 305. Further differently conserved sites like 307 and 308 also become apparent.