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A single bound Rap1 is a barrier to the strand displacement activity of Pol δ. (A) Substrate used in the assays. (B) Primer extension assays by PCNA-loaded Pol δ (25 nM) in the absence or presence of Rap1 (100 nM) or RPA (50 nM) and Rap1 (100 nM). The DNA is 25 nM. (C) Same primer extension assays as in (B) but with Pol δDV. Times (t) are: 10”, 20”, 30”, 1’, 2’, 4’, 6’, 10’.
