Table 5.
Non-compartmental pharmacokinetics parameters of Rs-1, Rs-1 glucuronide and Rs-1 glucuronide after a single oral or intravenous administration in rat plasma.
| Parameter | Unit | Oral (70 mg/kg, n=6) |
Intravenous (1.37 mg/kg, n=6) |
||||
|---|---|---|---|---|---|---|---|
| Rs-1 | Rs-1 glucuronide | Rs-1 sulfate | Rs-1 | Rs-1 glucuronide | Rs-1 sulfate | ||
| AUC0–t | µg ⋅ h/L | 1,162.0±200.6 | 16,924.3±7944.0 | 2,822.8±967.9 | 1,004.7±209.9 | 299.005±64.9 | 96.2±34.1 |
| AUC(0–∞) | µg ⋅ h/L | 1,181.9±193.9 | 18,758.3±9293.0 | 3,303.2±992.6 | 1,017.6±206.3 | 299.006±64.9 | 96.2±34.1 |
| MRT(0–t) | h | 5.6±0.6 | 7.4±1.5 | 7.4±0.9 | 1.5±0.2 | 2.02±1.4 | 0.4±0.3 |
| MRT(0–∞) | h | 6.0±0.6 | 9.7±2.5 | 12.3±4.6 | 2.0±0.4 | 2.02±1.4 | 0.4±0.3 |
| t1/2z | h | 4.2±1.6 | 7.3±1.8 | 9.5±4.8 | 5.8±1.6 | 1.1±0.5 | 0.3±0.2 |
| Tmax | h | 1.7±0.2 | 2.0±0.7 | 1.7±0.2 | 0.03±0.00 | 0.10±0.04 | 0.09±0.05 |
| Vz/F | L/kg | 379.7±180.4 | 45.1±15.6 | 298.1±144.0 | 12.2±5.8 | 6.6±2.6 | 5.4±3.0 |
| CLz/F | L/h/kg | 60.6±10.1 | 4.4±1.8 | 23.8±11.0 | 1.4±0.3 | 4.7±1.1 | 16.5±8.6 |
| Cmax | µg/L | 399.0±97.8 | 2,984.7±745.7 | 714.8±176.1 | 7,611.7±1,510.5 | 1,258.3±389.4 | 488.8±172.0 |
| F (%) | – | 2.3 | – | – | – | – | – |
–Not applicable.