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. 2016 Apr 22;6(3):189–197. doi: 10.1016/j.apsb.2016.03.009

Figure 3.

Fig. 3

Effects of parishin C on inhibition of LTP induced by soluble Aβ1–42 oligomers in rats. (A) showed original traces of PS before (1) and after (2) HFS in four groups. (B) Parishin C 20 mg/kg was given i.p. for two days before LTP recordings and was given i.p. 10 min before i.c.v. injection of 2 μmol/L soluble Aβ1–42 oligomers. (C) Parishin C 10 μmol/L was given i.c.v. before 2 μmol/L soluble Aβ1–42 oligomers injection. HFS was performed 60 min after injection of soluble Aβ1–42 oligomers in all experiments. Parishin C improved LTP induction significantly after Aβ treatment (P < 0.05). Data were shown as mean ± SEM, control group n=7, Aβ1–42 group n=5, pC (i.p.) group n=5, pC (i.c.v.) group n=5, ⁎P < 0.05 vs. control group, #P<0.05 vs. Aβ1–42 group.