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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Mol Pharmacol. 2012 Nov 27;83(2):439–453. doi: 10.1124/mol.112.082321

Fig. 8.

Fig. 8.

Metabolomic profiles of wild-type and 5F-dURes cells exposed or not (control) to 100 μM 5F-2′-dUrd for 8 hours. The level of 5F-2′dUrd in wild-type and 5F-dURes cells was not significantly different (A). After treatment with 5F-2′dUrd, the level of dUMP was much higher in wild-type (hatched bars) than in 5F-dURes cells (solid bars) (B). The abundance of TMP (C), TDP and TTP (not shown) was statistically identical in control and 5F-dURes cells, whether 5F-2′dUrd-treated or not. Experimental conditions as described in the legend to Figure 7. Hatched bars, wild-type; solid bars, 5F-dURes.