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. 2016 May 5;6:25438. doi: 10.1038/srep25438

Figure 1. The transcription factors circuit.

Figure 1

The gene network for the mutual and self-regulatory interactions between Nanog, Oct4 and Tet1. The curly lines indicate that Nanog and Tet1 interact at protein level forming a complex. The arrows indicate positive DNA regulation. The dotted arrow depicts assumed Tet1 self-interaction. The model shown in Methods is based on: Nanog and Tet1 complex regulates Oct4 and Tet1, Oct4 regulates Nanog, Oct4 and Tet1. All the gene interactions in the network are positive.