Figure 3. Time series of Nanog, Oct4 and Tet1 for various reprogramming scenarios and differentiation.

(a) Time series of the three factors when levels of factors over expression are varied: N_over = O_over = T_over = 0.1 -bottom plot, over-expression prameters values are 0.2 for middle plot and 0.3 for top plot. The yellow background corresponds to pre-iPS cells state. (b) Time series showing that addition of Nanog helps reprogramming when too low levels of exogenous Oct4 are induced. Nanog and Oct4 over-expression is depicted by cyan background. (c) Time series showing the differentiation process occurring under Lif withdrawal.