Table 5. Demographics and clinical features of patients with non-cirrhotic chronic liver disease(NC-CLD) and liver cirrhosis (LC) and within groups of well-classified or misclassified patients by Partial Least Square Discriminant Analysis (PLS-DA) models.
| All |
Well-classified |
Misclassified |
p* | ||||
|---|---|---|---|---|---|---|---|
| NC-CLD | LC | NC-CLD | LC | NC-CLD | LC | ||
| N (%) | 39 | 65 | 27(69.2) | 49(75.4) | 12(30.8) | 16(24.6) | – |
| Age (years), mean ± SD | 56.1 ± 13.6 | 63.6 ± 11.5 | 57.1 ± 14.2 | 65.0 ± 9.6 | 51.8 ± 21.3 | 59.1 ± 15.1 | ns/ns |
| Male, n (%) | 18(46.2) | 46(70.8) | 12(44.4) | 34(69.4) | 6(50.0) | 12(75.0) | ns/ns |
| Child-Pugh class A/B/C | – | 21/27/17 | – | 17/22/10 | – | 4/5/7 | ns/ns |
| Diabetes mellitus, n (%) | 5(12.8) | 27(41.5) | 3(11.1) | 20(40.8) | 2(16.7) | 7(43.7) | ns/ns |
| ALT (U/L), mean ± SD | 52.3 ± 48.7 | 52.2 ± 42.9 | 53.6 ± 41.8 | 48.7 ± 34.7 | 37.8 ± 24.1 | 54.5 ± 58.8 | ns/ns |
| Bilirubin (mg/dL), mean ± SD | 0.8 ± 0.5 | 2.6 ± 2.8 | 0.6 ± 0.2 | 2.3 ± 2.0 | 1.2 ± 0.8 | 2.8 ± 2.1 | ns/ns |
| eGFR (mL/min), mean ± SD | 84.6 ± 18.7 | 83.6 ± 36.4 | 82.7 ± 20.6 | 83.3 ± 35.6 | 84.2 ± 14.9 | 84.5 ± 39.6 | ns/ns |
| Smokers, n (%) | 9(23.1) | 18(27.7) | 6(22.2) | 13(26.5) | 3(25.0) | 5(31.3) | ns/ns |
| Lung disease, n (%) | 1(2.5) | 7(10.8) | 1(3.7) | 4(8.2) | 0(0) | 3(18.7) | ns/ns |
Difference between groups were calculated with ANOVA test for continuous variables or with χ2 test for categorical variables; Bonferroni correction was used for multiple testing; *p value for differences between well- and misclassified groups of patients with NC-CLD and LC, respectively; NC-CLD, non-cirrhotic chronic liver disease; LC, liver cirrhosis; ALT, Alanine Transaminase; eGFR, estimated glomerular filtration rate; ns, not significant (p > 0.05).