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. 2016 May 5;6:25502. doi: 10.1038/srep25502

Figure 7. RhoGEF overexpression induces RhoA/B/C activation.

Figure 7

(a) YFP/CFP ratios (±SEM) of HeLa cells transfected with the RhoA/B/C FRET sensors as indicated without (−) RhoA (n = 71), RhoB (n = 56), RhoC (n = 57) or with p63RhoGEF-DH overexpression (+) RhoA (n = 82), RhoB (n = 64), RhoC (n = 75). (b) YFP/CFP ratios (±SEM) of HeLa cells transfected with the RhoA/B/C FRET sensors as indicated without (−) RhoA (n = 71), RhoB (n = 43), RhoC (n = 57) or with p115RhoGEF overexpression (+) RhoA (n = 56), RhoB (n = 74), RhoC (n = 82). (c) YFP/CFP ratios (±SEM) of HeLa cells transfected with the RhoA/B/C FRET sensors as indicated without (−) RhoA (n = 50), RhoB (n = 56), RhoC (n = 64) or with XPLN overexpression (+) RhoA (n = 64), RhoB (n = 66), RhoC (n = 88). (d) YFP/CFP ratios (±SEM) of HeLa cells transfected with the RhoA/B/C FRET sensors as indicated without (−) RhoA (n = 50), RhoB (n = 56), RhoC (n = 64) or with RhoGDIα overexpression (+) RhoA (n = 53), RhoB (n = 53), RhoC (n = 55).