Skip to main content
. 2016 May 5;6:25492. doi: 10.1038/srep25492

Figure 4. Long-term effect of Bufei Yishen formula (BYF) on the expression of MMP-2, MMP-9 and TIMP-1 in the lung of chronic obstructive pulmonary disease (COPD) rats.

Figure 4

COPD rats were intragastricly treated with BYF (4.44 g/kg) and aminophylline (APL, 2.3 mg/kg) once daily from week 9 to 20. On week 32, the expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in the lung of COPD rats were evaluated by immunohistochemistry (magnification, ×100) (A). Quantitative analysis for the expression of MMP-2, MMP-9, and TIMP-1 in the lung of COPD rats (B). Values represent means ± SEM. *p < 0.05, **p < 0.01 vs. model.