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. 2016 May 5;6:25492. doi: 10.1038/srep25492

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The molecular functions of regulated proteins in COPD rats (A) and BYF-treated rats (B) were analyzed by ClueGO: functionally grouped network with terms as nodes linked, and functionally related groups partially overlap; the node size represents the term enrichment significance. The predominant function of the overlapping proteins between COPD and BYF-treated rats was analyzed using BiNGO, and the intuitive and customizable visual representation of the results were showed (C).