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. 2016 May 5;6:25492. doi: 10.1038/srep25492

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Using Metscape, the compound reaction network with compounds (hexagons) and metabolic enzymes (rounds) as nodes and reactions as edges was constructed. Inputted genes and proteins were shown in red, inputted compounds were shown in blue. (A) Representative metabolites-gene network of COPD model group. (B) Representative metabolite-gene network of BYF-treated group. (C) Representative metabolites-protein network of COPD model group. (D) Representative metabolite-protein network of BYF-treated group.