TABLE 3.
Pocket/groove volume around the active-site/Zn2+-coordinating-site in the 11 human APOBEC3 domains (solid green blobs in Figs. 7, 8) as calculated by SiteMap(Halgren; Maestro)(see Materials & Methods). In the context of double-domain APOBEC3 proteins, the catalytically active domain (indicated by *) consistently has a larger pocket volume than the inactive domain. All numbers rounded-off to one digit after decimal.
| A3 Domain | Pocket volume (A3) |
|---|---|
| A3A * | 4.1 ×102 |
| A3B-NTD | 3.0 ×102 |
| A3B-CTD * | 4.0 ×102 |
| A3C * | 2.1 ×102 |
| A3D-NTD | 0.7 ×102 |
| A3D-CTD * | 2.2 ×102 |
| A3F-NTD | 1.0 ×102 |
| A3F-CTD * | 1.9 ×102 |
| A3G-NTD | 0.6 ×102 |
| A3G-CTD * | 3.5 ×102 |
| A3H * | 1.6 ×102 |