. Author manuscript; available in PMC: 2016 May 5.

Published in final edited form as: Afr J Pharm Pharmacol. 2016 Mar;10(12):216–222. doi: 10.5897/AJPP2015.4488

Table 2.

Effect of M. scandens ethanolic and water extracts on seizure latency.

Treatment	Doses (mg/kg)	Seizure onset (s)	Seizure protection (%)	Level of significance
Diazepam	5	Nil	100	P<0.001^**
Distilled water	–	34 ± 9.0	37.5	P<0.001^**
MS WE	250	50 ± 2.0	75	P=0.9137
MS WE	500	106 ± 37	75	P=0.0023^*
MS WE	1000	78 ± 7.6	100	P=0.1453
MS EE	250	54 ± 9.7	50	P=0.8281
MS EE	500	46 ± 3.6	87.5	P=0.9671
MS EE	1000	63 ± 7.7	100	P=0.5229

Distilled water, Diazepam (5 mg/kg), M. scandens water extract (MS WE), M. scandens ethanolic extract (MS EE) were administered orally 60 min before the injection of PTZ (60 mg/kg, i.p); values are the mean ± S.E.M. for 8 rats.

P < 0.05 significantly different compared to vehicle treated group, Two-way ANOVA followed by Tukey’s test.

^**

P < 0.05 significantly different compared to the positive control treated group, Two- way ANOVA followed by post Tukey’s test.